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Hexes are special items in the inventory that add difficulty to the game.
They don't need to be active, but if activated, they provide extra 10% experience points and 5% more items for each Hex active.
Also, they are mandatory in order to complete some kind of Challenges.

Name Effect
Hex of Malice Monsters hit for 50% more damage and cause Cripple for 2 sec. on crit
Hex of Pain Victor Vran loses health periodically
Hex of Tenacity Monsters gain 120 armor and Regeneration
Hex of Time Monsters move and attack faster
Hex of Tyranny Some monsters become Champions. Tyrant Champions are not counted towards challenges